The Science of CoolSculpting
- CoolSculpting targets resistant fat, the fat resists the efforts of dieting and exercise.
- Treatment Day:
- Tissue is chilled. The lipid in the fat cells crystallizes before water can freeze in other tissues.
- 3 days later:
- Fat cells die by cellular suicide, a process termed apoptosis.
- 2 weeks later:
- The body responds to the dead fat tissue like it would any other injury. Immune cells enter treated area.
- Next 6-12 weeks:
- The immune system eats the dead fat tissue. The debris are moved to the liver and re-purposed.
- Next 4-6 weeks, treatment finale:
- The immune cells leave the treated area. The tissue has a significant reduction in fat cells. Otherwise, the tissue looks normal.
- Post Treatment: Long-lasting Results
- Fat cells have an extremely limited ability to regenerate in adults. The results persist for decades.
The Development of CoolSculpting
is based upon solid science. Studies show that a controlled chilling procedure kills just fat cells. It leaves skin, nerve and other tissues intact and unharmed.
The medical term for killing fat cells with cold is cryolipolysis. Cryolipolysis is safely performed with CoolSculpting®, a patented medical device.
The CoolSculpting procedure was cleared in Canada and Europe in 2009. It received FDA clearance as a class 2 medical device in 2010. At the time of this post, there have been over 5 million treatments performed, making CoolSculpting the world's most popular noninvasive fat reduction procedure.
It started with a Popsicle
The idea for CoolSculpting
came from two medical studies. The first study, published in 1970, is titled Popsicle Panniculitis
. This study investigated the formation of new dimples in the cheeks of toddlers.
The common factor was that all toddlers had teething pain treated with an orally placed frozen Popsicle®. It was determined that the prolonged exposure to cold resulted in the death of just fat cells. The void from the dead fat cells is the proposed mechanism for the formation of the new dimples.
The study also found that exposure to the cold did not harm the inner lining of the mouth, the cheek muscles or nerves. The dimples gradually filled in over time. There were no further complications as the children grew.
It is thought that the filling in of the dimples is due to the regeneration of fat cells in children. Prior to puberty, fat cells have the ability to quickly regenerate. After puberty, fat cells have a very limited ability to multiply.
The other study, published in 1980, is titled Equestrian Cold Panniculitis. This study investigated disfiguring fat loss to the inner thighs of women.
The common factor was that all the women had gone horseback riding in the winter upon frozen saddles. It was determined that the prolonged exposure to cold killed just fat cells.
Like the Popsicle study, there was no harm to skin, nerve or other tissues. Unlike the Popsicle study, the voids from the dead fat cells did not fill in over time. Since the fat loss occurred after puberty, it is assumed that the fat loss is essentially permanent.
Development of the Medical Device
The development of CoolSculpting as a medical device was a significant undertaking. The concept of using cryolipolysis as a fat reduction procedure was entirely novel. To assure safety, the FDA required investigational trials on animals before testing on humans.
The first animal study used pigs. CoolSculpting was performed on the back of the pigs on specific days prior to tissue collection. This allowed the progress of treatment to be monitored.
Summarizing the pig results, on the day of treatment, there were no tissue changes at all. Several weeks after treatment, the immune system had infiltrated the treatment area. By three months, the immune system had vacated the treatment area. The final result showed a significant reduction of fat cells, with no impact to skin, nerve or other tissue types.
With the success of the pig study, the FDA was able to authorize an investigation trial of CoolSculpting on humans. This trial was limited to abdominal tissue that was scheduled to be surgically removed from an elective panoplasty. A panoplasty is commonly referred to as a tummy tuck. The outcome of the human study essentially replicated safety and efficacy of the animal study.
Cryolipolysis: How Cold Kills Fat Cells
Human studies show that CoolSculpting triggers apoptosis
in fat cells. Apoptosis is a highly regulated process where a cell kills itself by creating digestive enzymes. Tissue examination shows that apoptosis is limited to just the fat cells.
Exactly why apoptosis is limited to just fat cells is not entirely understood. The working model is the cryolipolysis selectively damages the membrane of fat cells. Fat cells contain mostly fat, while other cell types contain mostly water.
CoolSculpting is able to crystallize the fat in a fat cell without freezing water in other cell types. Since the crystals being formed are just inside the fat cells, only the fat cells experience membrane damage triggering apoptosis.
The membrane damage model explains another clinical observation. Massaging tissue immediately after treatment kills another 68% of fat cells. Clearly, mechanical damage is involved with triggering apoptosis.
CoolSculpting Results Are Long Lasting
CoolSculpting results are also long lasting*. The first people to undergo CoolSculpting were test subjects treated in 2007. A follow-up study at 6 and 9 years post treatment demonstrates that the reduction of fat continues to persist. The persistence of results is because CoolSculpting kills fat cells and fat cells have only a very limited ability to regenerate in adults.
*Results and patient experience may vary
Follow this link for Clinical Studies